Serotonin and Sleep
by Monti, J. M.; Pandi-Perumal, S. R.; Jacobs, B. L.; Nutt, D. J.Edition: 1st
Format: Hardcover
Pub. Date: 2008-02-03
Publisher(s): Birkhauser
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Summary
The neurotransmitter serotonin plays a central role in physiological states like sleep in its various stages and wakefulness. Serotonin-modulating drugs are of clinical interest as antidepressants, anxiolytics and antipsychotics. The focus of this volume is on neuropsychopharmacology of serotonin and its role in sleep and wakefulness. It presents neurochemical, electrophysiological and neuropharmacological approaches to the understanding of the mechanism of action of serotonin and related substances of clinical interest. The contributing authors are leading experts in the field of sleep and neuropharmacology. The volume covers core as well as contemporary topics in the area and will be valuable for all professionals interested in interdisciplinary results in the context of drugs affecting the central nervous system.
Table of Contents
| Glossary | |
| Foreword | |
| Evolution of concepts | |
| Changing concepts on the role of serotonin in the regulation of sleep and waking | p. 3 |
| The dorsal raphe nucleus and median raphe nucleus: organization and projections | |
| Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus | p. 25 |
| Efferent and afferent connections of the dorsal and median raphe nuclei in the rat | p. 69 |
| Reciprocal connections between the suprachiasmatic nucleus and the midbrain raphe nuclei: A putative role in the circadian control of behavioral states | p. 103 |
| Serotonin receptors | |
| Localization of 5-HT receptors in the mammalian cortex | p. 135 |
| Molecular biology of 5-HT receptors | p. 155 |
| Electrophysiology of serotonergic neurons and the regulation of serotonin release | |
| Brain serotonergic neuronal activity in behaving cats | p. 185 |
| Electrophysiological studies on serotonergic neurons and sleep | p. 205 |
| Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons | p. 237 |
| Regulation of serotonin release by inhibitory and excitatory amino acids | p. 251 |
| Neurophysiological aspects of the regulation of serotonin neurons by the orexinergic system | p. 287 |
| Serotonin receptors and the regulation of behavioural state | |
| Serotonin and dreaming | p. 307 |
| Involvement of the 5-HT[subscript 1A] and the 5-HT[subscript 1B] receptor in the regulation of sleep and waking | p. 325 |
| Mechanisms involved in the inhibition of REM sleep by serotonin | p. 371 |
| Effect of 5-HT[subscript 2A/2B/2C] receptor agonists and antagonists on sleep and waking in laboratory animals and humans | p. 387 |
| Effect of the selective activation of serotonin 5-HT[subscript 3] receptors on sleep and waking | p. 415 |
| 5-HT[subscript 7] receptor modulation of sleep patterns | p. 439 |
| Sleep and waking in mutant mice that do not express various proteins involved in serotonergic neurotransmission such as the serotonergic transporter, monoamine oxidase A, and 5-HT[subscript 1A], 5-HT[subscript 1B], 5-HT[subscript 2A], 5-HT[subscript 2C] and 5-HT[subscript 7] receptors | p. 457 |
| Circadian control by serotonin and melatonin receptors: Clinical relevance | p. 477 |
| Serotonergic mechanisms contributing to arousal and alerting | p. 501 |
| Relevance of serotonin to clinical disorders and drug actions | |
| Contribution of chemosensitive serotonergic neurons to interactions between the sleep-wake cycle and respiratory control | p. 529 |
| Obstructive sleep apnea: The potential for serotonergic pharmacotherapies | p. 555 |
| The effects of antidepressant drugs and 5-HT[subscript 1A] agonists on human sleep | p. 569 |
| The effect of typical and atypical antipsychotic drugs on sleep of schizophrenic patients | p. 587 |
| Subject Index | p. 611 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
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