Mass Spectrometry: Instrumentation, Interpretation, and Applications
by Editor: Rolf Ekman; Editor: Jerzy Silberring; Editor: Ann M. Brinkmalm; Dominic M. Desiderio (University of Tennessee Health Science Center); Nico M. Nibbering (Vrije Universiteit in Amsterdam)Format: eBook
Pub. Date: 2008-12-01
Publisher(s): Wiley
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Summary
With contributions from noted experts from Europe and North America, Mass Spectrometry Instrumentation, Interpretation, and Applications serves as a forum to introduce students to the whole world of mass spectrometry and to the many different perspectives that each scientific field brings to its use. The book emphasizes the use of this important analytical technique in many different fields, including applications for organic and inorganic chemistry, forensic science, biotechnology, and many other areas. After describing the history of mass spectrometry, the book moves on to discuss instrumentation, theory, and basic applications.
Table of Contents
| Foreword | |
| Contributors | |
| Instrumentation | |
| Definitions and Explanations | |
| References | |
| A Mass Spectrometer's Building Blocks | |
| Ion Sources | |
| Mass Analyzers | |
| Detectors | |
| References | |
| Tandem Mass Spectrometry | |
| Tandem MS Analyzer Combinations | |
| Ion Activation Methods | |
| References | |
| Separation Methods | |
| Chromatography | |
| Electric-Field Driven Separations | |
| References | |
| Interpretation | |
| Introduction to Mass Spectra Interpretation: Organic Chemistry | |
| Basic Concepts | |
| Inlet Systems | |
| Physical Bases of Mass Spectrometry | |
| Theoretical Rules and Approaches to Interpret Mass Spectra | |
| Practical Approaches to Interpret Mass Spectra | |
| References | |
| Sequencing of Peptides and Proteins | |
| Basic Concepts | |
| Tandem Mass Spectrometry of Peptides and Proteins | |
| Peptide Fragmentation Nomenclature | |
| Technical Aspects and Fragmentation Rules | |
| Why Peptide Sequencing? | |
| De Novo Sequencing | |
| Peptide Derivatization Prior to Fragmentation | |
| Acknowledgments | |
| References | |
| Online Tutorials | |
| Optimizing Sensitivity and Specificity in Mass Spectrometric Proteome Analysis | |
| Quantitation | |
| Peptide and Protein Identification | |
| Success Rate and Relative Dynamic Range | |
| Summary | |
| References | |
| Applications | |
| Doping Control | |
| References | |
| Oceanography | |
| References | |
| "Omics" Applications | |
| Introduction | |
| Genomics and Transcriptomics | |
| Proteomics | |
| Metabolomics | |
| SPace Sciences | |
| Introduction | |
| Origins | |
| Dynamics | |
| The Space MS Paradox | |
| A Brief History of Space MS | |
| GENESIS and the Future | |
| References | |
| Bioterrorism | |
| What is Bioterrorism? | |
| Some Historical Accounts of Bioterrorism | |
| Geneva Protocol of 1925 and Biological Weapons Convention of 1972 | |
| Categories of Biothreat Agents | |
| Challenges | |
| MS Identification of Biomarker Proteins | |
| Development of New Therapeutics and Vaccines Using Immunoproteomics | |
| References | |
| Imaging of Small Molecules | |
| SIMS Imaging | |
| Biological Applications (Cells, Tissues, and Pharmaceuticals) | |
| Catalysis | |
| Forensics | |
| Semiconductors | |
| The Future | |
| References | |
| Utilization of Mass Spectrometry in Clinical Chemistry | |
| Introduction | |
| Where are Mass Spectrometers Utilized in Clinical Applications? | |
| Most Common Analytes Detected by Mass Spectrometers | |
| Multianalyte Detection of Clinical Biomarkers, The Real Success Story | |
| Quantitative Profiling | |
| A Clinical Example of the Use of Mass Spectrometry | |
| Demonstrations of Concepts of Quantification in Clinical Chemistry | |
| Polymers | |
| Introduction | |
| Instrumentation, Sample Preparation | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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