DNA Origami Structures, Technology, and Applications

DNA origami technology is a growing scientific field that has found applications in chemistry, materials science, physics, biophysics, biology and medicine. This book brings together leading contributors from all fields to explain current developments and to share ideas about future directions. First discussion in the book is about structural design and assembly systems leading to the applications. Interdisciplinary studies are then classified as follows and discussed in detail: DNA origami used for creating new functional materials (combining chemistry and materials science), DNA origami for single-molecule analysis and measurements (as applied in physics and biophysics), and DNA origami for biological detection, diagnosis and therapeutics (medical and biological applications).

Masayuki Endo, PhD, is an associate professor in the Department of Chemistry at Kyoto University, Japan. He received his PhD from the Department of Chemistry and biotechnology, Tokyo Unviersity in 1997. Prof. Endo’s research work involves DNA nanotechnology and single-molecule analysis.

1. Multidisciplinary studies toward structural and assembly system

1-1. Mechanical change of structure 1

1-2. Mechanical change of structure 2

1-3. Mechanical change of structure 3

1-4. 3D assembly system

1-5. Direct observation of the DNA origami assembly

2. Multidisciplinary studies toward chemistry and material sciences

2-1. Chemical reactions in DNA origami

2-2. Sensing and Switching using DNA origami

2-3. Chemical system in DNA origami

2-4. DNA pore and applications

2-5. DNA origami channel

3. Multidisciplinary studies toward physics and biophysical applications

3-1. DNA PAINT

3-2. Super resolution imaging

3-3. Chiral nanoparticle & nanorod

3-4. Force sensor

3-5. DNA cage (optical tweezers)

4. Multidisciplinary studies toward Biological and medical applications

4-1. DNA origami delivery to the cell

4-2. DNA origami in living organism

4-3. DNA nanorobot