
Biomaterials: A Nano Approach
by Ramakrishna; SeeramBuy New
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Summary
Table of Contents
Foreword | p. xiii |
Preface | p. xv |
Acknowledgments | p. xvii |
About the Book | p. xix |
Authors | p. xxi |
Overview of Biomaterials | p. 1 |
Introduction | p. 1 |
Biomaterials: From Then to Now | p. 3 |
Impact of Biomaterials | p. 9 |
Characteristics of Biomaterials | p. 11 |
Classification of Biomaterials | p. 14 |
Metallic Biomaterials | p. 18 |
Ceramic Biomaterials | p. 19 |
Polymeric Biomaterials | p. 19 |
Composite Biomaterials | p. 20 |
Surface Modification of Biomaterials | p. 20 |
Recent Trends in Biomaterials | p. 22 |
Nanobiomaterials: A New Generation Biomaterial | p. 22 |
Processing of Nanobiomaterials | p. 23 |
Sol-Gel Processing | p. 23 |
Biomimetic Processing | p. 24 |
Tissue Engineering Approach | p. 26 |
Summary | p. 28 |
Glossary | p. 29 |
References | p. 32 |
Basics of Human Biology | p. 35 |
Introduction | p. 35 |
Structure and Function of the Human Body | p. 35 |
Chemical Level | p. 36 |
Cellular Level | p. 37 |
Nucleus | p. 38 |
Cytoplasm | p. 39 |
Cell Membrane | p. 39 |
Transport across the Cell Membrane | p. 40 |
Tissue Level | p. 41 |
Epithelial Tissue | p. 42 |
Connective Tissue | p. 43 |
Muscle Tissue | p. 43 |
Nerve Tissue | p. 44 |
Organ Level | p. 44 |
Skin | p. 44 |
Bone | p. 46 |
System Level | p. 49 |
Glossary | p. 51 |
References | p. 54 |
Further Reading | p. 55 |
Degradation and Corrosion of Biomaterials | p. 57 |
Introduction | p. 57 |
Surface Properties | p. 57 |
Degradation of Biomaterials | p. 62 |
Corrosion of Biomaterials | p. 63 |
Galvanic Corrosion | p. 66 |
Crevice Corrosion | p. 66 |
Pitting Corrosion | p. 66 |
Intergranular Corrosion | p. 67 |
Stress Corrosion | p. 67 |
Fretting Corrosion | p. 68 |
Methods of Corrosion Testing | p. 68 |
Biocompatibility of Implants | p. 70 |
In Vitro Test Methods | p. 71 |
In Vivo Test Methods | p. 73 |
Case Study | p. 74 |
Summary | p. 77 |
Glossary | p. 77 |
References | p. 78 |
Further Reading | p. 79 |
Failure and Tribology of Biomaterials | p. 81 |
Introduction | p. 81 |
Deformation Mechanics | p. 82 |
Elastic Deformation | p. 84 |
Plastic Deformation | p. 85 |
Deformation Analysis of Biomaterials | p. 86 |
Fracture Mechanics | p. 88 |
Classification of Fracture | p. 91 |
Brittle Fracture | p. 92 |
Ductile Fracture | p. 93 |
Brittle to Ductile Transition of Biomaterials | p. 94 |
Fracture Toughness | p. 96 |
Toughness Analysis of Biomaterials | p. 100 |
Fatigue Mechanics | p. 104 |
Fatigue Analysis of Biomaterials | p. 107 |
Tribology | p. 109 |
Friction | p. 109 |
Wear | p. 111 |
Tribological Analysis of Biomaterials | p. 114 |
Case Study | p. 117 |
Summary | p. 119 |
Glossary | p. 119 |
References | p. 121 |
Further Reading | p. 121 |
Nanoscale Phenomena | p. 123 |
Introduction | p. 123 |
Nanoscale Phenomena | p. 125 |
Properties at Nanoscale | p. 126 |
Processing of Nanostructured Materials | p. 129 |
Top-Down Methods | p. 130 |
Bottom-Up Methods | p. 134 |
Characterization Techniques | p. 139 |
X-Ray Diffraction and Scattering Methods | p. 140 |
Electron Microscopy | p. 141 |
Scanning Probe Microscopy | p. 143 |
Light Scattering Techniques | p. 145 |
Gas Adsorption Measurements | p. 147 |
Environmental and Safety Aspects of Nanomaterials | p. 148 |
Summary | p. 155 |
Glossary | p. 155 |
References | p. 157 |
Further Reading | p. 159 |
Metallic Biomaterials | p. 161 |
Introduction | p. 161 |
Metallic Biomaterials | p. 161 |
Stainless Steels | p. 163 |
Cobalt-Chromium Alloys | p. 168 |
Titanium and Titanium-Based Alloys | p. 169 |
Shape Memory Alloys | p. 172 |
Dental Amalgam Alloys | p. 175 |
Noble and Other Metals | p. 175 |
Nanostructured Metallic Implants | p. 176 |
Case Study | p. 179 |
Summary | p. 183 |
Glossary | p. 184 |
References | p. 185 |
Ceramic Biomaterials | p. 187 |
Introduction | p. 187 |
Bioceramics | p. 187 |
Nearly Inert Bioceramics | p. 189 |
Porous Bioceramics | p. 193 |
Bioactive Bioceramics | p. 194 |
Bioactive Glasses | p. 195 |
Calcium Phosphate Ceramics | p. 197 |
Bioresorbable Bioceramics | p. 200 |
Nanostructured Bioceramics | p. 201 |
Synthesis and Characterization of Nano Bioceramics | p. 201 |
Synthesis and Characterization of Nano Alumina | p. 202 |
Synthesis and Characterization of Nano Calcium Phosphate Ceramics | p. 208 |
Case Study | p. 211 |
Summary | p. 212 |
Glossary | p. 213 |
References | p. 214 |
Polymeric Biomaterials | p. 217 |
Introduction | p. 217 |
Polymerization Process | p. 217 |
Addition Polymerization | p. 217 |
Condensation Polymerization | p. 218 |
Types of Polymers | p. 219 |
Factors Influencing the Properties of Polymers | p. 221 |
Molecular Weight | p. 221 |
Molecular Structures | p. 221 |
Intermolecular Forces | p. 222 |
Polymer Crystallinity | p. 223 |
Polymer Characterization | p. 224 |
Polymers as Biomaterials | p. 224 |
Classification of Polymeric Biomaterials | p. 225 |
Naturally Derived Polymers | p. 226 |
Collagen | p. 227 |
Gelatin | p. 228 |
Chitosan | p. 228 |
Synthetic Polymers | p. 229 |
Nonbiodegradable Synthetic Polymers | p. 229 |
Poly(methyl methacrylate) | p. 229 |
Poly(ethylene) | p. 230 |
Poly(ethylene terephthalate) | p. 230 |
Biodegradable Synthetic Polymers | p. 230 |
Poly(lactic acid) | p. 230 |
Poly(glycolic acid) | p. 231 |
Poly(lactic-co-glycolic acid) | p. 231 |
Polymeric Nanobiomaterials | p. 231 |
Processing of Polymer Nanofibers: Current Scenarios | p. 232 |
Drawing | p. 233 |
Template Synthesis | p. 233 |
Self-Assembly | p. 237 |
Phase Separation | p. 237 |
Electrospinning: A New Approach | p. 239 |
Experimental System | p. 240 |
Spinning Mechanism | p. 240 |
Electrospun Polymer Nanofibrous Scaffolds | p. 248 |
Collagen Nanofibrous Scaffold | p. 248 |
Gelatin Nanofibrous Scaffold | p. 250 |
Chitosan Nanofibrous Scaffold | p. 250 |
Poly(L-lactic acid) Nanofibrous Scaffold | p. 251 |
Poly(glycolic acid) Nanofibrous Scaffold | p. 252 |
Poly(lactic-co-glycolic acid) Nanofibrous Scaffold | p. 254 |
Biomedical Applications of Polymer Nanofibers | p. 254 |
Medical Prostheses | p. 255 |
Dental Restoration | p. 256 |
Wound Dressing | p. 256 |
Drug Delivery | p. 258 |
Tissue Scaffolds | p. 259 |
Summary | p. 259 |
Glossary | p. 260 |
References | p. 261 |
Composite Biomaterials | p. 263 |
Introduction | p. 263 |
Classification of Composite Biomaterials | p. 265 |
Fibrous Composite Biomaterials | p. 265 |
Particulate Composite Biomaterials | p. 266 |
Biological Responses to Composite Biomaterials | p. 269 |
Biomedical Applications of Composite Biomaterials | p. 269 |
Bone Fracture Repair | p. 271 |
Bone Plates and Screws | p. 273 |
Joint Replacements | p. 275 |
Total Hip Replacement | p. 276 |
Bone Graft Materials | p. 278 |
Dental Applications | p. 280 |
Dental Restorative Materials | p. 281 |
Dental Post | p. 282 |
Dental Arch Wires and Brackets | p. 283 |
Evolution of Nanocomposite Biomaterials | p. 284 |
Nanocomposites: A New Class of Nanobiomaterials | p. 285 |
Conventional Nanocomposites | p. 286 |
Biomimetic Nanocomposites | p. 288 |
Tissue-Engineered Nanocomposites | p. 290 |
Nanocomposites for Growth Factor Delivery | p. 292 |
Summary | p. 295 |
Glossary | p. 295 |
References | p. 297 |
Nanobiomaterials for Tissue Regeneration | p. 299 |
Introduction | p. 299 |
Concept of Tissue Engineering | p. 300 |
The Promise of Stem Cells | p. 301 |
Mesenchymal Stem Cells | p. 302 |
Nanobiomaterials: A New Generation Scaffolding Material | p. 304 |
Characteristics of a Scaffold | p. 305 |
Types of Scaffolding Materials | p. 306 |
Ceramic Nanobiomaterials | p. 307 |
Polymeric Nanobiomaterials | p. 307 |
Scaffold Designing Using Nanobiomaterials | p. 308 |
Tissue-Engineered Ceramic Nanobiomaterials | p. 308 |
Tissue-Engineered Polymeric Nanobiomaterials | p. 311 |
Patterning of Biomaterials for Cell Engineering | p. 314 |
Chemical Patterning | p. 316 |
Patterning by Microcontact Printing | p. 317 |
Topographical Patterning | p. 320 |
Nanoimprint Lithography | p. 321 |
Tissue-Engineered Products: The Artificial Skin and Cartilage | p. 324 |
Case Study | p. 326 |
Summary | p. 328 |
Glossary | p. 330 |
References | p. 333 |
Index | p. 335 |
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